Securely attach the Endo Cap to the distal end of the endoscope. Place the tip of the endoscope 2 cm above the squamocolumnar junction (SCJ). Obtain visual confirmation that the sensors are properly positioned on the mucosal wall to capture quality measurements. Take initial capture and retract the Endo Cap 3 cm for the next capture. This is repeated three (3) times to successfully complete mucosal integrity measurements along 12 cm of the esophagus.

Instant results in the differentiation of GERD and EoE during endoscopy. Follow-up appointments are minimized, providing peace of mind and quicker treatment

MiVu™ Mucosal Integrity Testing System

MiVu provides a complete picture of mucosal integrity with real-time results during a routine endoscopy. This revolutionary technology instantly differentiates between GERD, EoE, and Non-GERD, empowering physicians to improve clinical efficiency and enhance patient care.

See MiVu in Action

100% Sensitivity for EoE^vi

96% Positive Predictive Value for Reflux^viii

95% Specificity for GERD^viii

Impedance Measurement

What is Mucosal Integrity Testing?

Mucosal integrity is influenced by dilated intercellular spaces (DIS), a key histologic biomarker of GERD and EoE that inversely correlates with mucosal integrity measurements. MiVu measures electrical impedance along 12 cm of the esophageal lining, providing a real-time display of mucosal integrity contour pattern and disease probability.

MiVu assesses esophageal mucosal integrity, which directly correlates with tissue damage caused by reflux and eosinophilic esophagitis. Unlike pH testing, which captures only acid reflux events that reach a specific level of the esophagus at a single point in time, MiVu detects long-term changes in esophageal health.

This cutting-edge approach may minimize false negatives and reduce the diagnostic uncertainty often seen with traditional pH testing.

Video Demonstration

Watch MiVu in Action During Endoscopy

See how MiVu integrates seamlessly into a routine endoscopy with the Endo Cap attached to the distal end of the endoscope.

When the Endo Cap is properly positioned against the mucosal lining, it captures immediate readings across 12 cm of the esophagus.

The Components of MiVu Mucosal Integrity Testing System

PriZm® Cart System

The system consists of the following components:

PriZm Central Unit
24” LCD medical grade touch screen
Keyboard & Mouse
Computer
Printer
Ergonomic cart
Zvu^® Functional GI Software*

*Zvu is utilized for esophageal manometry, mucosal integrity testing, and reflux monitoring.

MiVu Esophageal Endo Cap

It is placed on the endoscope tip and is required to perform MiVu testing.

A single-use Endo Cap is compatible with an endoscope diameter of 9.9 mm.

MiVu Cable

Connects the Endo Cap to the PriZm Central Unit

Easy-to-Identify

MiVu Simplifies Assessing Esophageal Diseases

This chart^viii illustrates how mucosal impedance values differ for various esophageal conditions.

Non-GERD patients typically tend to have higher impedance (ohms) values across the entire esophagus, indicating a normal mucosa.
Patients with active EoE consistently show lower impedance across all measured points, reflecting mucosal damage along the entire esophagus.
Esophagitis patients tend to have lower impedance values closer to the gastroesophageal junction (GEJ), which gradually increase and normalize proximally. This same pattern exists for individuals without esophagitis, but positive pH.

Discover more about MiVu, including its clinical application in daily practice, with a recent on-demand webinar on our Diversatek University platform.

Why MiVu

MiVu vs. Traditional pH Monitoring

MiVu Clinical Evidence & Publications

MiVu References

Why MiVu

Impactful

What are the Benefits of Using MiVu?

MiVu empowers gastroenterologists with real-time data to aid in the differentiation of GERD, EoE, and Non-GERD. By simplifying and enhancing diagnostic workflows, MiVu improves procedural efficiency and reduces diagnostic latency.

Easy-to-Use

Securely attach the Endo Cap to the distal end of the endoscope.
Place the tip of the endoscope 2 cm above the squamocolumnar junction (SCJ).
Obtain visual confirmation that the sensors are properly positioned on the mucosal wall to capture quality measurements.
Take initial capture and retract the Endo Cap 3 cm for the next capture.
This is repeated three (3) times to successfully complete mucosal integrity measurements along 12 cm of the esophagus.

Streamlined Diagnostics

By capturing four mucosal impedance readings in just minutes, patient care can be streamlined with a single, in-procedure test, potentially eliminating the need for multiple tests and follow-ups.

MiVu may eliminate the need for additional hospital-based reflux testing, including 24-48 hour pH monitoring and biopsies, providing a faster, easy-to-use diagnostic tool.

Endoscopy centers and ambulatory surgery centers (ASCs) can perform MiVu in their facilities, providing more convenient care for patients while expanding diagnostic capabilities and revenue opportunities.

Patient-Friendly

MiVu eliminates the burden on both the patient and your team - no patient compliance, follow-up visits, or uncomfortable probes required. It enables faster diagnosis and more efficient treatment planning.

MiVu is performed during a patient’s scheduled endoscopy, reducing the need for additional appointments. Faster results lead to faster treatment plans, improving overall patient experience.

Results in 2 Minutes

MiVu vs. Traditional pH Monitoring

Improved Technology

MiVu vs Traditional pH Monitoring?

MiVu has numerous benefits when compared to traditional ambulatory reflux monitoring, including:

Aid in the detection of GERD and EoE in minutes
May reduce false negatives and inconclusive results
Reduce patient discomfort & eliminate the need for patient compliance
Integrate seamlessly into your current endoscopy workflow

Feature	MiVu	Traditional pH Monitoring
Specificity for GERD^viii	95%	64%
Positive Predictive Value^viii	96%	40%
Test Time	2 Minutes	24-48 Hours
Measures	Mucosal integrity & reflux impact	Only acidity (pH)
Detects Non-Acid Reflux?	Yes	No
Sensitivity for EoE^vi	100%	Not designed for EoE
Patient Friendly?	Single Procedure	Requires catheter placement

MiVu Clinical Evidence & Publications

Review the Science

Access a comprehensive library of clinical evidence and publications in support of MiVu

Clinical Evidence & Publications

MiVu References

i Dent J. Gastro-oesophageal reflux disease. Digestion 1998;59: 433–445.
ii Patel DA, Vaezi MF. Utility of esophageal mucosal impedance as a diagnostic test for esophageal disease. Curr Opin Gastroenterol 2017;33:277–284.
iii Wenner J, Johansson J, Johnsson F, et al. Optimal thresholds and discriminatory power of 48-h wireless esophageal pH monitoring in the diagnosis of GERD. Am J Gastroenterol 2007;102:1862–1869.
iv Kessels SJM, Newton SS, Morona JK, et al. Safety and efficacy of wireless pH monitoring in patients suspected of gastroesophageal reflux disease: a systematic review. J Clin Gastroenterol 2017;51:777–788.
v Caroline Barrett & Yash Choksi & Michael F. Vaezi, Mucosal Impedance: a New Approach to Diagnosing Gastroesophageal Current Gastroenterology Reports (2018) 20:33 Reflux Disease and Eosinophilic Esophagitis.

vi Choksi Y, Lal P, Slaughter JC, et al. Esophageal mucosal impedance patterns discriminate patients with eosinophilic esophagitis from patients with GERD. Clin Gastroenterol Hepatol 2018;16:664–671 e1.
vii Dhyanesh A. Patel, Tina Higginbotham, James C. Slaughter, Muhammad Aslam, Elif Yuksel, David Katzka, C. Prakash Gyawali, Melina Mashi, John Pandolfino, and Michael F. Vaezi, Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders, Gastroenterology 2019;156:1617–1626.
viii Ates, F., Yuksel, E. S., Higginbotham, T., Slaughter, J. C., Jetté, M. E., Lee, A. S., ... & Vaezi, M. F. (2015). Mucosal impedance discriminates gastroesophageal reflux disease from non-gastroesophageal reflux disease conditions. Gastroenterology, 148(2), 334–343
MiVu™ Mucosal Integrity Testing System is covered by one or more of the following patents: US 11,291,382, US 10,321,867 and US 9,814,408.

Intuitive

Zvu® Functional GI Software

Zvu is a powerful, user-friendly software platform designed for acquiring, managing, and analyzing GI motility data. With customizable options, Zvu allows providers to tailor diagnostic testing to their procedural needs and preferences, consistently delivering reliable and easy-to-read results.

Easy-to-Interpret

How to Read MiVu Data

Zvu Software visualizes ohms values utilizing distinct color patterns that facilitate interpretation and aid physicians in diagnosing GERD, EoE, and Non-GERD. This innovative testing system assesses 10 cm or more of the mucosal lining to quantify esophageal health.

Hover over the bars and the image to see how the data is presented.

Clinical Education

Your Expertise Drives Exceptional GI Care

Diversatek University (DU) offers comprehensive education and training, online, on-site, and in-person, to ensure your team receives a personalized learning experience that supports your goals and enhances clinical confidence.

Go to Diversatek University

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